Annette Cyr grew up in Southern California, spending an influential year in Arezzo, Italy and one in Paris, France. The years in Europe gave her direct contact with the grand tradition of European painting with which she has been mischievously working ever since.

Upon earning her MFA from Yale University, Cyr moved to New York City. Cyr's painting has been awarded numerous awards including an NEA Fellowship in Painting, as well as grants from Art Matters, Inc. and NYSCA, and residency fellowships at the MacDowell, Yaddo, Millay, Hambidge and Dorland art colonies.

She currently divides her time between New York and California, as Associate Professor and Lead Faculty of Art at National University, San Diego, CA. She is the founding Director of 214a Gallery + Project Space in San Diego and develops successful online studio art courses.
For the past decade, Cyr has been making digital films, balancing the solitude of painting with the camaraderie of filmmaking. Recent films, viewable on Vimeo.com, include Cyr's film poem, "Evangeline"; the short documentary, "A Poet's Life", a visit to the poet Jane Hirshfield; and the "Artists of the 21st Century" series, a spoof on PBS series Art 21 about the predicaments of an artist, Annette Souris.